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These structural features are important in peptide research because small changes in peptide sequence, stereochemistry, terminal modification, or side-chain conjugation can affect receptor interaction, enzymatic stability, conformational behavior, and model-system pharmacology
Empagliflozin: In adult patients with type 2 diabetes mellitus with mild (eGFR: 60 to less than 90 mL/min/1.73 m2), moderate (eGFR: 30 to less than 60 mL/min/1.73 m2), and severe (eGFR: less than 30 mL/min/1.73 m2) renal impairment and patients on dialysis due to kidney failure, AUC of empagliflozin increased by approximately 18%, 20%, 66%, and 48%, respectively, compared to subjects with normal renal function
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