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As anticipated, EVs derived from VDAC1-deficient cells exhibited markedly reduced VDAC1 and P-gp levels compared to control EVs ( Figure 3C ), suggesting a critical association between EV-derived VDAC1 protein and chemoresistance acquisition

The major drawback of this strategy is the possible loss of metabolites that are not expected to be widely detected (e.g., truly absent data), such as dietary or exposure compounds

Herniated discs affect roughly 2% of the general population at any given time, with the L4-L5 and L5-S1 levels accounting for approximately 95% of lumbar herniations