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Flanagan RJ, Mant TG

The matrix effect was investigated by comparing the signal of analytes in post-extraction plasma to the signal of analytes in neat solution

The 2006 Ionescu paper documented that pulsatile GH secretion persists even under continuous receptor stimulation, suggesting somatotroph-intrinsic pulsatile release dynamics independent of receptor-binding temporal patterns (PMID 17018654)