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Mechanistic studies typically combine receptor or cell-based assays with analytical verification of peptide identity and integrity
For some carefully selected patients, that opens the door to eventually reducing the drug burden rather than escalating it: a lower biologic frequency, a smaller methotrexate dose, or getting off chronic steroids
In 7 out of 10 simulations in c-state, FAs entered the protein between TM5 and TM6, where they remained, interacting with residues K22, R79, and R279, while the acyl chain extended into the lipid bilayer
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