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This data from an unselected, population-based cohort highlights the need for improved understanding of risk factors associated with the development of cirrhosis in HH to better inform population-wide screening

Boghozian et al., 2023), which is prompted by a variety of signaling molecules, including fractalkine (Cao et al., 2019) and the purine, ATP (Davalos et al., 2005), extracellular peroxiredoxin (prx6) (Kuang et al., 2014), several Rho guanosine triphosphate hydrolyases (GTPases), like Rac, Cdc42, and Rho (Choi et al., 2011), CXCL12 (Huang et al., 2017), and apoptosis signal-regulating kinase 1 (ASK1) (Cheon et al., 2017)

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