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When he sequenced it, the result was striking: exendin-4 was approximately 50% identical to a human hormone called glucagon-like peptide-1 (GLP-1), which had recently been identified as a key regulator of blood sugar
Frontiers in Neurology, 10, 824
The main symptom is diarrhea, described by experts as sometimes explosive, with other symptoms including loss of appetite, weight loss, cramping, bloating and increased gas
Moreover, PDE5is act peripherally on blood vessels and require sexual stimulation to be effective, which may not address issues of low sexual desire or psychological barriers to arousal
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