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At the currently approved maximum dose of 14mg, the PIONEER clinical trials showed weight loss of approximately 4-5kg (about 4-5% of body weight) over 26 weeks in patients with type 2 diabetes
The goal is to provide fuel without triggering the nausea that many GLP-1 users experience when eating too much before exercise
The Phase 2 clinical trial showed roughly 2-3 kg more fat loss than placebo over 12 weeks, with no impact on blood sugar, insulin, IGF-1, or any hormonal marker
Adequate hydration is essential before, during, and after plasma donation
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