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72 CAR T-cell therapy directly targets tumor surface antigens via engineered CARs, completely bypassing the tumor cell-intrinsic MHC class I antigen presentation pathway, whereas CAR-NK cell therapy integrates CAR-directed cytotoxicity with the innate missing-self recognition of NK cells, enabling efficient elimination of tumor cells with downregulated or absent MHC class I expression and thereby directly addressing resistance mechanisms
Several questions remain unsolved, including the connection between melanocyte depletion and stem cell exhaustion, the underlying degenerative mechanisms and the biological mediators of cell death
43 Integrins are generally accepted to adopt at least three distinct conformations: a low-affinity bent conformation, an extended closed conformation with intermediate affinity, and an extended open conformation characterized by high ligand affinity
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