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Deletion of PPAR-, specifically at the DN3 and DN4 stages of murine thymocyte maturation, reduces thymus cellularity as a result of impaired proliferation, causing subsequent peripheral lymphopenia in PPAR- KO mice (116)
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Patients using injectable protocols (250-500 mcg daily) reported symptom improvements within 2-3 weeks, while those using oral formulations (500-1000 mcg daily) required 4-6 weeks for comparable benefits
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