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After removing patients with a prior gastroesophageal reflux disease (GERD) diagnosis, people on GLP-1 medications still had a notably higher chance of developing chronic cough compared to others taking different diabetes drugs
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GLP-1s appear generally safe for people with RA who are taking them for other conditions, but more targeted research is needed
doi: 10.1056/NEJMoa0802987 8 MendivilCOAmaya-MontoyaMHernndez-VargasJARamrez-GarcaNRomero-DazCPrez-LondooAet al
However: Bioavailability is still significantly lower than injection (estimated 5-25%) Absorption is highly variable based on saliva production, food timing, and individual anatomy Higher doses are needed to compensate for lower absorption, increasing cost No clinical trials have validated sublingual CJC-1295/Ipamorelin dosing For patients who absolutely can't tolerate injections, sublingual may be worth discussing with your physician, but expectations should be adjusted accordingly
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