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Metformin inhibits Akt palmitoylation through FASN downregulation, which prevents its membrane translocation and activation, consequently blocking MAPK-mediated inflammatory signaling in LPS-induced macrophages
These are typically mild to moderate and improve with gradual dose increases
Results can be long-lasting but not permanent without maintenance
Apoptosis and glutathione: Beyond an antioxidant Wu G., et al
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