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The glutamate residue is linked through its side-chain carboxyl, giving a gamma-glutamyl bond rather than a standard alpha-peptide bond, which is why the molecule resists most intracellular peptidases and is cleaved chiefly by gamma-glutamyl transpeptidase at the cell surface

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Data from epidemiological evidence, such as the EPIC-Oxford Study or the Adventist cohorts, show quite broadly how a healthy lifestyle, including PA and exercise, along with plant-predominant (including vegan) diets, can contribute to long-term sustainable health (100, 385, 386)