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Reactions of the Oxidative Phase: Conversion of glucose-6-phosphate to 6-phosphogluconolactone by glucose-6-phosphate dehydrogenase : irreversible, rate limiting step of the pathway inhibited by NADPH which competes for NADP + binding NADPH produced, C=O double bond formed Km for NAD + is 1000-fold higher than for NADP +
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