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Additionally, apart from IR being a new effective target for systemic PD treatment, studies on T2DM have found that ROS production and mitochondrial damage in muscle tissues of hyperglycemic mice can be normalized with antioxidant treatment and blood glucose control (56), suggesting that T2DM treatment strategies could provide new insights and strategies for future PD research and treatment
Beyond the reduced availability of energy substrates, enzyme deficiencies also play a significant role in the impaired energy metabolism characteristic of AD (Gibson et al., 2012)
(2016), and Bayer Pharma AG Berlin (2016)
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