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Very high concentrations or excessive application frequency are more likely to trigger irritation without a proportional benefit, and the dose-response relationship for cosmetic GHK-Cu is not precisely defined in the literature
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Its primary mechanism is the upregulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) two of the most important proteins governing neuronal survival, plasticity, and the formation of new neural connections
Almost all of the evidence is from small trials or animal work, so we dont know about chronic use, safety for offspring, or late adverse effects
