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While short-term increases in cortisol support adaptive energy regulation, chronic elevationsespecially from prolonged or frequent fastingmay promote muscle catabolism, reduce metabolic health, and impair insulin sensitivity [44]
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Thus, there is an imperative need to discover the precise dysregulated pathways involved in chemoresistance as well as to develop new strategies and alternative therapies to combat cancer chemoresistance
This framework helps guide peptide selection in patients with different risk profiles or histories of malignancy
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