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Domestic Cold-Chain for a Multi-Component Blend Multi-peptide blends introduce additional stability considerations because each component has different temperature sensitivity thresholds and degradation kinetics

Take the Mary St exit from Acosta Expy 18 min (18.6 mi) Continue onto FL-202 W 7.1 mi Keep left to stay on FL-202 W 4.9 mi Take the exit onto I-95 N toward Jacksonville 4.8 mi Take exit 348 toward Interstate 95 service Rd 0.2 mi Keep left, follow signs for Downtown/Main St Bridge/Acosta Brg 0.5 mi Continue onto Interstate 95 service Rd 0.7 mi Continue onto Acosta Expy 0.2 mi Take the Mary St exit 0.1 mi Take Prudential Dr to your destination 2 min (0.3 mi) Turn right onto San Marco Blvd 0.1 mi Turn right onto Prudential Dr 0.2 mi Turn left Destination will be on the right 240 ft Follow Ratliff Rd to US-1 S/US-23 S/New Kings Rd 2 min (0.5 mi) Head southeast on Hurst Rd toward Ratliff Rd 89 ft Turn left onto Ratliff Rd 0.5 mi Follow US-23 S to Prudential Dr in Jacksonville

Eating disorders Pre-clinical and mechanistic studies We retrieved only a few pre-clinical and mechanistic articles relevant to GLP-1RAs for eating disorders (Supplementary Section 5)

Figure 1: Structural comparison of GLP-1 receptor agonists