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Caraballo C, Herrin J, Mahajan S, Massey D, Lu Y, Ndumele CD, Drye EE, Krumholz HM
A multifunctional poly(amino acid) nanomedicine (PM-DPA/R848) has been developed that encapsulates the TLR7/8 agonist resiquimod (R848) within a nanocarrier composed of poly(L-methionine) and alendronate-functionalized DSPE-PEG ( Calcium carbonate (CaCO3)-based nanosystems have been engineered to simultaneously neutralize the acidic TME and reprogram TAM polarization
Special attention is given to modifications like fatty acid conjugation
Laboratory research suggests that vitamin C may enhance neutrophil chemotaxis, support lymphocyte proliferation, and aid the oxidative burst mechanism involved in pathogen elimination
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