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doi: 10.1139/bcb-2023-0018 29 LuGWuZShangJXieZChenCZhangC
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The published Phase 2 obesity trial measured weight change at 24 weeks and again at 48 weeks, reporting dose-dependent mean reductions of up to 17.5% and up to 24.2% respectively
Specifically, in women who are postmenopausal, exogenous estrogen causes homocysteine levels to drop, but prior to menopause, excess estrogen may increase homocysteine.[ref][ref] Both high and low homocysteine levels increase all-cause mortality, with the caveat that the increase in mortality risk is only seen if homocysteine is not low due to vitamin intake
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