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July 16 Product: Orexos OX124 Indication: Opioid overdose Second time is not the charm for Orexo, as the FDA denied its application for OX124, a high-dose naloxone nasal spray for the rescue treatment for opioid overdose
To investigate the effect of gene knockout on l-cysteine and GSH degradation, the engineered strains were cultured in the flasks as described above and the cells were collected by centrifugation (6000 rpm, 4 C for 5 min) after two washes with 50 mM phosphate buffer (pH7.0)
However, this approach is not routine first-line treatment in UK practice, is considered off-label, and requires good patient adherence and clinical follow-up
