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Concerning amyloid and tau, the results were mixed: polyphenolic extract PEBG (500 or 2500 mg/kg, p.o., for 4 months) showed no significant effects on proteins like beta-secretase 1 and metalloproteinase domain 10 [21], whereas quercetin (80 mg/kg, p.o., for 21 days or 16 weeks) reduced cathepsin B and tau phosphorylation [35, 39]
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