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Administration of semaglutide at the dose regimen of ~ 90 g/kg/day failed to evidence significant weight loss but more importantly, led to alteration of cortical bone microarchitecture, represented by lower cortical thickness, and ultimately to a significant decrease in bone strength [69]
The critical structural modification is the attachment of an 18-carbon fatty diacid chain via a gamma-glutamic acid spacer at position 26
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