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In the multiple-dose trial, semaglutide exposure was approximately twofold higher with 40 versus 20 mg oral semaglutide in healthy males, in accordance with dose proportionality, and was similar between healthy males and males with T2D

Current evidence doesnt point to a specific causal relationship that directly links GLP-1 drugs and microbial overgrowths, but the underlying mechanics and possible resulting effects certainly warrant a degree of caution

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