The NLRC4 Inflammasome Receptors for Bacterial Flagellin and Type III Secretion Apparatus
The endogenous antioxidant system, including glutathione (GSH) and antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-px) and glutathione S-transferase (GST) acts as a scavenger of the accumulated ROS, and thereby protects organs and cells from ROS-induced oxidative damage (3)
Nausea represents the most frequently reported adverse reaction, affecting a significant proportion of patients, particularly during the initial weeks of therapy or following dose increases
Also, DFX can alleviate the lipid peroxidation and endothelial dysfunction in MAECs, inhibiting the occurrence of ferroptosis, and then improving AS lesion ( 4.4 Radical-Trapping Antioxidants RTAs, reacts with chain-carrying peroxyl radicals to produce non-reactive free radicals (Li and Pratt 2015), which destroys the autoxidation of chain-propagating peroxyl radicals (Kajarabille and Latunde-Dada 2019)
