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The review also noted that GHK-Cus copper complexation ability raises Cu2+ penetration rates across the stratum corneum, and documented the development of formulation innovations including the TriHex peptide system that combine GHK-Cu-type tripeptides with hexapeptides to produce synergistic upregulation of regenerative genes and suppression of aberrant collagen deposition
It amplifies the signal to make more GH
Key finding: Upregulated SOD, glutathione S-transferase, and endogenous antioxidant genes while suppressing pro-oxidant expression reversing age-related oxidative decline
Many individuals can resume modified activity during mid-phase, with progressive loading helping direct tissue remodeling along functional lines
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