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Both TRIUMPH-2 and TRIUMPH-3 met their primary endpoints, expanding the clinical evidence for retatrutide in two of obesitys most significant comorbidities: type 2 diabetes and established cardiovascular disease

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Combined with semaglutide gastric emptying delay, very high fat intake can cause nausea, bloating, and reflux that makes eating feel genuinely unpleasant

However, only 41.8% stayed on treatment at 6 months 109 , in line with the available literature reporting disappointingly low adherence to liraglutide for obesity management and raising concerns about its role in the lifelong challenge of BW control and weight-related complications 110