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Initial weight changes may appear within 46 weeks, though meaningful weight reduction (typically 5% or more of initial body weight) generally occurs over 36 months
Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo
Proper cycle planning accounts for desensitization, protocol cycling, monitoring, and exit strategy
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