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Based on the systematic review[16] and meta-analysis[21] of 37 randomized controlled trials, the dosage range for L-carnitine supplementation varied between 250 mg/day to 4000 mg/day

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However, increases in circulating NAD precursors do not necessarily translate into proportional expansion of tissue-specific redox capacity, as precursor metabolism and systemic NAD pools are strongly influenced by microbial conversion and circulatory metabolism [109]

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