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Oral Ozempic Delivers Mixed Results on Alcohol Use Semaglutide in pill form shows promise for alcohol use disorder STUDY: Schacht JP et al, American Journal of Psychiatry 2026 STUDY TYPE: Randomized, double-blind, placebo-controlled trial FUNDING: National Institute on Alcohol Abuse and Alcoholism, National Center for Advancing Translational Sciences, Hewit Family Foundation, anonymous donor Background GLP-1 drugs like semaglutide (Ozempic) have a mix of positive and negative data in alcohol use disorder, but most of the research has involved non-treatment seeking populations, which often differ in their responses

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In this experimental platform, the anti-gravity calf-muscle group (gastrocnemius (Gas), plantaris (Pla), and soleus (Sol) muscles) and shank muscles (tibialis anterior (TA) and extensor digitorum longus (EDL)) were collected from four experimental groups of 8-week-old C57BL/6J male mice: i) control (without any treatment), ii) 5-days suspension-disuse, iii) 3-days LASSS pre-administration (about 50 g in drinking water/g body weight/day) followed by 5-days suspension-disuse treatment without LASSS supplementation, and iv) 3-days GSSSG pre-administration followed by suspension-disuse treatment ( n = 3 mice per group)

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