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Wiley, London, pp 2340 Bravo-Ruiz I, Medina M, Martnez-Poveda B (2021) From food to genes: transcriptional regulation of metabolism by lipids and carbohydrates

Metabolic dysfunction-associated steatotic liver disease (formerly called NAFLD) affects roughly 30% of adults globally and has no approved pharmacotherapy

The most commonly reported flu-like manifestations include: Nausea and general malaise the most frequent side effect, with incidence varying by product and dose (ranging from approximately 15-40% depending on the specific medication and dosage) Fatigue and low energy levels often described as feeling generally unwell or 'run down' Headaches ranging from mild to moderate intensity Dizziness or light-headedness particularly when standing up quickly, which may reflect dehydration or, in patients also taking insulin or sulfonylureas, possible hypoglycaemia Loss of appetite which, whilst therapeutically beneficial, can contribute to feeling unwell Mild gastrointestinal upset including occasional vomiting or abdominal discomfort These symptoms typically emerge because GLP-1 medications significantly alter gastrointestinal function and metabolic processes

Increases collagen synthesis