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In the Dapagliflozin and Prevention of Adverse outcomes in Heart Failure (DAPA-HF) study, conducted in 4,744 patients with existing HF (New York Heart Association [NYHA] class II, III, or IV) and reduced ejection fraction (EF 40%) regardless of the presence of T2DM, dapagliflozin 10 mg reduced the risk of HF exacerbation or death from cardiovascular disease (CVD) by 26% (hazard ratio [HR], 0.74
Skins ability to bounce back depends on: Younger skin often adapts more easily due to higher collagen and elastin reserves, allowing it to retract as volume is lost
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