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Experimental literature on excess SAM also supports the idea that methylation balance is not governed by SAM alone
References Stier H
The LD control group was particularly distinct from the other groups in the unweighted UniFrac and BrayCurtis dissimilarity analyses plots, suggesting that animals exposed to the same diet at an early age in life diet develop similar microbiome profiles that persist even after an acute change in diet
If vitamin B12 injections are not suitable or necessary for your situation, alternative supplementation methods such as oral supplements or patches may be recommended by your healthcare professional
