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The constipation, however, hasn't abated, she said

Take pictures and save some clothes from before, and youll see the changes happening as you go

The standard protocol starts at 1mg weekly for 4 weeks, then titrates up monthly: 2mg, 4mg, 8mg, reaching 12mg maintenance

When to seek urgent medical help: Whilst most gastrointestinal side effects are mild and self-limiting, participants and clinicians should be alert to the following red-flag symptoms, which require prompt medical assessment: Severe or persistent abdominal pain (which may indicate pancreatitis or gallbladder disease) Repeated vomiting or an inability to keep fluids down Signs of dehydration (such as dizziness, dark urine, or reduced urine output) Yellowing of the skin or eyes (jaundice) Anyone who suspects they have experienced a side effect from a medicine including medicines received as part of a clinical trial should report it via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)