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Poor solubility can lead to low absorption, compromised bioavailability, and inaccurate assay results, ultimately increasing development time and cost
Of interest is the strict conservation of the four cysteines (Cys14, Cys47, Cys101 and Cys169) that confer peculiar redox sensitivity to this enzyme
High levels of iron in the body can be deposited in the brain which is involved in some neurodegenerative diseases such as PD and AD ( TABLE 1 Diseases related to the involvement of abnormal iron metabolism
Ethics declarations Ethics Approval Considering the nature of this review, which synthesizes data from previously published studies, ethical approval was not deemed necessary
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