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One study found that after injecting high doses of vitamin B12 (specifically cyanocobalamin) into rodents, the B12 stayed in the bloodstream for a relatively short period, with a half-life ranging from 20 to 50 minutes

Again, if it does happen, we'll get creative and go other routes as well

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One of the most interesting features of one carbon metabolism is that reaction velocities are often affected not just by substrate and product concentrations and enzyme activities but also by the concentrations of substrates in distant parts of the reaction network that act as allosteric activators or inhibitors of the enzyme