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Recent Findings Preliminary data suggest that GLP-1 RA can modulate crucial pathways in the pathogenesis of IBD, such as chronic inflammation circuits, intestinal tight junctions, and gut microbiome dysbiosis, setting the stage for human trials to investigate the role of these agents in the treatment of IBD among people with or without diabetes and obesity

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It also faces certain development challenges, showing an overall trend of coexisting potential and opportunities, which can be summarized in the following aspects

According to the UK SmPC, Mounjaro should be discontinued immediately if pancreatitis is suspected