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Two factors compound: drug exposure scales with body weight (lighter body = more drug per pound), and physiological response varies by metabolic and cardiovascular phenotype
mostly gone by weeks 24 Diarrhea: ~3 days per episode Constipation: average 47 days
2026;38(3):e70161 Munoz P
A recent meta-analysis of RCTs reported improvements in several metabolic parameters, including markers of glycemic control, insulin sensitivity, and lipid metabolism, demonstrating that targeted modulation of the gut ecosystem can shift clinically relevant endpoints in humans ( Moving from mechanistic observations to clinical implementation will require a structured translational roadmap: Methodological Standardization: Standardizing microbiome sampling, sequencing platforms (transitioning from 16S rRNA to high-resolution shotgun metagenomics), and bioinformatic pipelines to improve reproducibility across international cohorts
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