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Key differences in tirzepatide vs semaglutide mechanism of action relevant to drug design are: Clinical comparisons between tirzepatide and the more balanced RG7697, whose efficacy approximated liraglutide, confirm that receptor activity ratio and signaling bias are as consequential as dual engagement itself

We believe these results will guide clinical translation for the use of more efficient and safer therapies for IH and possibly for other vascular anomalies in which SOX18 plays a role