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In a follow-up study, the same group demonstrated that HPDL deficiency induces a lethal form of mitochondrial encephalopathy and, importantly, supplementation with HPDL-derived intermediates (4-HMA or 4-HB) was sufficient to alleviate disease symptoms
Regarding T-DXd toxicity, gastrointestinal and hematological events were the most common AEs of any grade, with neutropenia being the most common AE of grade 3
The role of biopolymers in MRAB biofilm integration was also revealed by the enzymatic part of the treatments, which resulted in a significant reduction in biofilm biomass and distinctive disruption in biofilm architecture
85, 1334 (IARC Press, Lyon, France, 2004)
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