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When deficiency is suspected based on clinical features (fatigue, paraesthesia, cognitive changes) or risk factors (vegan diet, gastric surgery, certain medications), serum B12 measurement guides appropriate intervention
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Why it matters for body composition: GH plays a crucial role in lipolysis (fat breakdown) and muscle protein synthesis
Chronic, high-frequency dosing that disrupts normal pulsatile GH secretion is a theoretical long-term concern that has not been characterized in long-duration human studies
For active individuals and fitness enthusiasts, this is a particularly exciting finding, as it suggests MOTS-C may help the body perform more efficiently at a cellular level
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