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For example, the phase-3 SURMOUNT-1 trial showed Mayas tirzepatide (Zepbound) led to ~20.9% weight loss vs 3.1% on placebo after 72 weeks ( [18] )

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The clinical relevance is straightforward

Weight loss recommendations may be particularly important for patients at highest risk for weight gain and cardiovascular morbidity, such as young/premenopausal patients, postmenopausal patients with estrogen receptorpositive disease on endocrine therapy, and/or preexisting cardiovascular disease risk factors