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In the nucleus, FOXO4 activates the transcription of genes encoding antioxidant enzymes like manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GPX)
Measurement of malondialdehyde, glutathione, and glutathione peroxidase in SLE [PMID: 24497363] Laboratory literature summary: Measurement of malondialdehyde, glutathione, and glutathione peroxidase in SLE research subjects
Oral supplements are generally milder and easier to use, but results may take longer
AOD 9604 works, but it's not dramatic in the short term
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