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Looking more closely at the effect of the ex vivo stimulus, LPS stimulation resulted in a lower OCR compared to unstimulated cells for basal respiration, ATP production, and maximal respiration

Collectively, these findings suggest that metformin may alleviate H 2 O 2 -induced oxidative damage, ameliorate chondrocyte apoptosis, and protect against ECM degeneration

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Its strong association with obesity has prompted researchers to evaluate the effects of weight-loss GLP therapies, specifically semaglutide and tirzepatide, on MASH pathology