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Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients as many as 1 in 5 may not respond well to the medications

Others surprise even experienced researchers

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The questionnaire screens for conditions that might make semaglutide unsafe, including personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2, or severe gastrointestinal conditions