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GHK-Cu: Nrf2 Antioxidant Biology in Ageing Nrf2-Keap1 Axis and Aged Antioxidant Capacity In aged tissues, the Nrf2-Keap1 antioxidant response declines Nrf2 nuclear translocation is impaired by increased Keap1 expression and reduced p62 competition for Keap1 binding, leading to progressive loss of HO-1, NQO1, and GPx antioxidant capacity

This "controlled copper transport" is a key concept in GHK-Cu research: the peptide functions simultaneously as a copper transporter and as a signaling molecule that independently activates cellular processes

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