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Perler BK, Friedman ES, Wu GD

It seems these medications are particularly good at quieting down the constant thoughts about food and cravings

However, big pharma will still have the ability to charge premium prices for innovator molecules, especially those with higher efficacy (eg retatrutide) and those aimed at niche patient populations rather than the mass market (eg survodutide, which is targeting MASH endpoints in clinical trials)

For instance, HFDS-induced obesity reduces the production of granzyme and cytokines (TNF-, TNF-), which in turn causes the depletion of CD8+ tumor-infiltrating lymphocytes (TILs) and ultimately speeds up tumor growth in a mouse model of colorectal cancer [37,38,39]