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The development of this ischemic penumbra is limited in time by a cascade of reactions in response to the initial ischemia followed by subsequent reperfusion
In a forced swimming test, a reduction of the immobility time in bpc 157 (10 microg, 10 ng x kg(-1) i.p.) treated rats corresponds to the activity of the 15 mg or 40 mg (i.p.) of conventional antidepressants, imipramine or nialamide, respectively, given according to the original porsolts protocol
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Kidney and liver function are particularly important to assess, as these organs play a central role in processing and eliminating glutathione-bound toxins
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