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Dual-acting peptide with prolonged glucagon-like peptide-1 receptor agonist and glucagon receptor antagonist activity for the treatment of type 2 diabetes
In the inactive GCGR structure, ECL1 forms a -hairpin conformation and runs in parallel with the stalk to form a compact -sheet module
Encouragingly, the picture isn't fixed: at ENDO 2025, researchers reported that higher protein intake may help prevent muscle loss in these patients
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