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Adding keto to this combination creates a three-way intervention that requires understanding how all three interact

RESULTS Mechanism of Action of GLP-1 Receptor Agonists Glucagon-like peptide-1 (GLP-1) is an incretin hormone primarily released from neuroendocrine L cells in the ileum and colon, supplemented by a minor production from alpha cells in the pancreas and neurons in the nucleus tractus solitarius

Primary systemic carnitine deficiency Primary systemic carnitine deficiency is a rare, autosomal recessive disorder caused by mutations (including deletions) in the SLC22A5 gene coding for carnitine transporter protein OCTN2 (organic cation transporter novel 2) (33)

This makes it challenging to draw solid conclusions about their impact on weight loss