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DOI: 10.1056/NEJMoa1402584 [Google Scholar] Wollin L, Distler JHW, Redente EF, Riches DWH, Stowasser S, Schlenker-Herceg R, et al

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The introduction of a subcutaneous formulation, approved in September 2023, offered patients a more convenient administration option compared to the traditional intravenous infusion, enhancing its competitiveness against similar therapies like Novartis Kesimpta

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The activation of the NLRP3 inflammasome mediates the cleavage of caspase-1 and the secretion of the IL-1 proinflammatory cytokine, ultimately inducing cell death through a process known as pyroptosis

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However, MNTI occasionally manifests as higher-density lesions with clearer boundaries between surrounding tissues

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